Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus
نویسندگان
چکیده
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic human herpesvirus. KSHV is associated with three cancers in the human population: KS, primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KS is the leading cause of cancer in HIV-infected individuals. In this review, we discuss the most recent discoveries behind the mechanisms of KSHV latency maintenance and lytic replication. We also review current therapies for KSHV-associated cancers.
منابع مشابه
REPORTS Expression of Human Herpesvirus 8-Encoded Cyclin D in Kaposi’s Sarcoma Spindle Cells
Background: Human herpesvirus 8 (HHV-8) DNA sequences have been detected in Kaposi’s sarcoma, in primary effusion lymphoma (an unusual highgrade non-Hodgkin’s lymphoma seen primarily in patients with acquired immunodeficiency syndrome [AIDS]), and in Castleman’s disease (a rare lymphoproliferative disorder); however, proof that HHV-8 is involved in the pathogenesis of these diseases remains to ...
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متن کاملDetection of human herpesvirus-6 DNA in bone marrow biopsies from patients with multiple myeloma and Waldenstrom’s macroglobulin-
patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...
متن کاملDetection of human herpesvirus-6 DNA in bone marrow biopsies from patients with multiple myeloma and Waldenstrom’s macroglobulin-
patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...
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Kaposi's sarcoma-associated herpesvirus (KSHV) is a human pathogenic γ-herpesvirus strongly associated with the development of Kaposi's Sarcoma and B cell proliferative disorders, including primary effusion lymphoma (PEL). The identification and functional investigation of non-coding RNAs expressed by KSHV is a topic with rapidly emerging importance. KSHV miRNAs derived from 12 stem-loops locat...
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عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2016